Cholesteryl Lignocerate Hydrolysis in Adrenoleukodystrophy
نویسندگان
چکیده
منابع مشابه
Triglyceride and cholesteryl ester hydrolysis
Cultured rabbit aortic smooth muscle cells were converted to foam cells by exposure to sonicated lipid droplets of defined composition using an inverted culture technique. Uptake of the lipid droplets by the cells was shown to be dependent on the time of exposure to the droplets and on the mass of droplets presented to the cells. A comparison of the hydrolysis of triolein and cholesteryl oleate...
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In the present experiments we have measured the liberation of [‘4C]adenosine derivatives and lactate from ‘synaptosome beds’ (de Belleroche & Bradford, 1972), prelabelled with [8-14C]adenosine and superfused with glucose/bicarbonate medium with or without metabolic inhibitors and depolarizing agents. To interpret our findings we have also measured ATP, ADP and AMP of the superfused synaptosomes...
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Rat adrenal cortical cells have been prepared by collagenase dissociation of trypsin-treated adrenal tissue. The content and compositions of cholesteryl ester, phospholipid, and triglyceride fatty acids compare favorably with those of undissociated rat adrenal tissue. During 2-hour control incubations of adrenal cortical cells, steroidogenesis was not detected, and the levels of sterol ester, p...
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The mechanisms of hydrolysis and accumulation of cholesteryl oleate-lipid droplets prepared in vitro were studied in acid cholesteryl-esterase-deficient fibroblasts (GM00863, GM03111). Acid cholesteryl esterase activity was reduced in both GM00863 and GM03111 (8.9% and 17.4% of the normal level, respectively), while neutral cholesteryl esterase activity was highly stimulated in GM03111. The hyd...
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Hormone-sensitive lipase (HSL) regulates the hydrolysis of acylglycerol and cholesteryl ester (CE) in various organs, including adipose tissues. However, the hepatic expression level of HSL has been reported to be almost negligible. In the present study, we found that mice lacking both leptin and HSL (Lep(ob/ob)/HSL(-/-)) showed massive accumulation of CE in the liver compared with Lep(ob/ob)/H...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1980
ISSN: 0031-3998
DOI: 10.1203/00006450-198014010-00006